Enantioselective Total Synthesis of Hirsutin through a three-component domino-Knoevenagel/hetero-Diels-Alder reaction.
|
Natural products are important lead structures for the development of pharmaceutical compounds; almost 60% of the
known anti-cancer drugs are based on natural products. Though in most cases not the active substances but analogues or derivatives
are used. In my group bioactive natural products and analogues of alkaloids, steroids, chromanes, terpenes, antibiotics,
spinosyns, carbohydrates and cytostatics are prepared using catalytic procedures and domino reactions. Enantioselective Total Synthesis of Hirsutin through a three-component domino-Knoevenagel/hetero-Diels-Alder reaction. |
| L.F. Tietze, S. Dietz, N. Böhnke, M. A. Düfert, I. Objartel, D. Stalke | Three-Component Domino Knoevenagel/Hetero-Diels–Alder Reaction for the Synthesis of the Amino Sugars 2-Acetoxyforosamine and 2-Acetoxyossamine – Experimental and Theoretical Results.
Eur. J. Org. Chem. 2011, 6574-6580. |
|
| L.O.A. Manguro, J.O. Midiwo, L.F. Tietze, P. Hao | Triterpene saponins of Maesa lanceolata leaves.
Arkivoc 2011, 172-198. |
|
| L.F. Tietze, L. Ma | Synthesis of Novel 1-Hydroxyquinolones with High Anti-Toxoplasma Activity.
Heterocycles 2010, 82, 377-396. |
|
| L.F. Tietze, S. Biller, T. Wolfram | First Enantioselective Total Synthesis of the Reported Structure of (R)-(+)-Orizaterpenyl Benzoate
Using an Asymmetric Allylation of a Prochiral Ketone in a Domino Process.
Synlett 2010, 2130–2132. | |
| L.F. Tietze, A. Düfert | Multiple Pd-catalyzed reactions in the synthesis of natural products, drugs, and materials.
Pure Appl. Chem. 2010, 82, 1375-1392. |
|
| L.L. Bajohr, L. Ma, C. Platte, O. Liesenfeld, L.F. Tietze, U. Groß, W. Bohne | In-vitro and in-vivo activity of 1-hydroxy-2-alkyl-4(1H)quinolone derivatives against Toxoplasma gondii.
Antimicrob. Agents Chemother. 2010, 54, 517-521. |
|
| M. Schubert, A.N. Melnikova, N. Mesecke, E.K. Zubkova, F. Fortte, D.R. Batashev, I. Barth, N. Sauer, Y.V. Gamalei, N.S. Mamushina, L.F. Tietze, O.V. Voitsekhovskaja, K. Pawlowski | Two novel disaccharides, rutinose and methylrutinose, are involved in carbon metabolism in Datisca glomerata.
Planta 2010, 231, 507-521. |
|
| S.A. Opiyo, J.A. Ogur, L.O.A. Manguro, L.F. Tietze, H. Schuster | A new sterol diglycoside from Conyza floribunda.
S. Afr. J. Chem. 2009, 62, 163-167. |
|
| L.F. Tietze, N. Tölle, D. Kratzert, D. Stalke | Efficient Formal Total Synthesis of the Erythrina Alkaloid (+)-Erysotramidine Using a Domino Process.
Org. Lett. 2009, 11, 5230–5233. |
|
| L.F. Tietze, N. Böhnke, S. Dietz | Synthesis of the Deoxyaminosugar(+)-D-Forosamine via a Novel
Domino-Knoevenagel-Hetero-Diels-Alder Reaction.
Org. Lett. 2009, 11, 2948-2950. |
|
| L.F. Tietze, C.A. Vock, I.K. Krimmelbein, L. Nacke | Synthesis of Novel Structurally Simplified Estrogen Analogues with Electron-Donating Groups in Ring A.
Synthesis 2009, 2040-2060. |
|
| K.M.D. Islam, M. Dilcher, C. Thurow, C. Vock, I.K. Krimmelbein, L.F. Tietze, V. Gonzalez, H. Zhao, C. Gatz | Directed evolution of estrogen receptor proteins with altered ligand-binding specificities.
PEDS 2009, 22, 45-52. |
|
| D.B. Werz, H. Schuster, L.F. Tietze | Fast and Efficient Preparation of an α-Fucosyl Building Block by Reductive
1,2-Benzylidene Ring Opening Reaction.
Synlett 2008, 1969-1972. |
|
| L.F. Tietze, D.A. Spiegl, F. Stecker, J. Major, C. Raith, C. Grosse | Stereoselective Synthesis of 4-Dehydroxydiversonol Employing Enantioselective Palladium-Catalysed Domino Reactions.
Chem. Eur. J. 2008, 14, 8956-8963. |
|
| L.F. Tietze, C.C. Brazel, S. Hölsken, J. Magull, A. Ringe | Total Synthesis of Polyoxygenated Cembrenes.
Angew. Chem. 2008, 120, 5324-5327;
Angew. Chem., Int. Ed. 2008, 47, 5246-5249. |
|
| I. Elghamry, L.F. Tietze | Microwave assisted synthesis of novel annealed porphyrins.
Tetrahedron Lett. 2008, 49, 3972–3975. |
|
| L.F. Tietze, C.A. Vock, I.K. Krimmelbein, J.M. Wiegand, L. Nacke, T. Ramachandar, K.M.D. Islam, C. Gatz | Synthesis of Novel Structurally Simplified Estrogen Analogues.
Chem. Eur. J. 2008, 14, 3670-3679. |
|
| L.F. Tietze, I. Krimmelbein | Enantioselective Total Synthesis of the Oral Contraceptive Desogestrel via a Double Heck Reaction.
Chem. Eur. J. 2008, 14, 1541-1551. |
|
| L.F. Tietze, N. Tölle, C. Noll | Highly Efficient Domino Reaction for the Synthesis of the Erythrina and B-Homoerythrina Alkaloid Skeleton.
Synlett 2008, 525-528. |
|
| L.F. Tietze, T. Redert, H.P. Bell, S. Hellkamp, L.M. Levy | Efficient Synthesis of the Structural Core of Tetracyclines by a Palladium-Catalyzed Domino Tsuji–Trost–Heck–Mizoroki Reaction.
Chem. Eur. J. 2008, 14, 2527-2535. |
|
| L.F. Tietze, H. Braun, P.L. Steck, S.A.A. El Bialy, N. Tölle, A. Düfert | Efficient synthesis of cephalotaxine- and deoxyharringtonine
analogues by a trimethylaluminium-mediated domino reaction.
Tetrahedron 2007, 6437-6445. |
|
| L.F. Tietze, G. Brasche, A. Grube, N. Böhnke, C. Stadler | Synthesis of Novel Spinosyn A Analogues by Pd-Mediated Transformations.
Chem. Eur. J. 2007, 13, 8543-8563. |
|
| L.F. Tietze, K. M. Gericke, I. Schuberth | Synthesis of Highly Functionalized Anthraquinones and Evaluation of Their Antitumor Activity.
Eur. J. Org. Chem. 2007, 4563-4577. |
|
| L.F. Tietze, R.R. Singidi, K.M. Gericke | Total Synthesis of the Proposed Structure of the Anthrapyran Metabolite
δ-Indomycinone.
Chem. Eur. J. 2007, 13, 9939-9947. |
|
| L.F. Tietze, R.R. Singidi, K.M. Gericke, H. Böckemeier, H. Laatsch | Isolation, Enantioselective Total Synthesis and Structure Determination of the Anthrapyran Metabolite.
Eur. J. Org. Chem. 2007, 5875-5878. |
|
| L.F. Tietze, N. Böhnke, G. Brasche | Preparation of (2R)-2-acetoxy-D-forosamine for the total synthesis of spinosyns.
Arkivoc 2007, 12-21. |
|
| L.F. Tietze, C. Stadler, N. Böhnke, G. Brasche, A. Grube | Synthesis of Enantiomerically Pure Cyclopentene Building Blocks.
Synlett 2007, 485-487. |
|
| L.F. Tietze, K.M. Gericke, R.R. Singidi, I. Schuberth | Novel strategies for the synthesis of anthrapyran antibiotics: discovery of a
new antitumor agent and total synthesis of (S)-espicufolin.
Org. Biomol. Chem. 2007, 5, 1191-1200. |
|
| L.F. Tietze, T. Kinzel | Synthesis of natural products and analogs using multiple
Pd-catalyzed transformations.
Pure Appl. Chem. 2007, 79, 629-650. |
|
| L.F. Tietze, G. Brasche, C. Stadler, A. Grube, N. Böhnke | Multiple Palladium-Catalyzed Reactions for the Synthesis of Analogues of the Highly Potent
Insecticide Spinosyn A. Angew. Chem. 2006, 118, 5137-5140;
Angew. Chem., Int. Ed. 2006, 45, 5015-5018. |
|
| L.F. Tietze, N. Böhnke, G. Brasche | Preparation of (2R)-2-acetoxy-D-forosamine for the total synthesis of spinosyns.
Arkivoc 2007, 12-21. |
|
| L.F. Tietze, C. Güntner, K.M. Gericke,I. Schuberth and G. Bunkoczi | A Diels-Alder Reaction for the Total Synthesis of the Novel Antibiotic Antitumor Agent Mensacarcin. Eur. J. Org. Chem. 2005, 2459-2467. |